COP9 signalosome complex subunit 2 Antibody

Product Discontinued

COP9 signalosome complex subunit 2 Antibody Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residues 275 and 325 of human COP9 constitutive photomorphogenic homolog subunit 2 using the numbering given in entry NP_004227.1 (GeneID 9318).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: COPS2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:1000-1:10000
• Application Notes: By Western blot, this antibody recognizes a band at ~50 kDa, representing CSN2 protein. *The investigator should determine the optimal working dilution for a specific application.
• Control:

  COP9 signalosome complex subunit 2 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Tris-Citrate/Phosphate (pH 7.0 - 8.0)
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for COP9 signalosome complex subunit 2 Antibody

• Alien homolog
• ALIEN
• COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
• COP9 signalosome complex subunit 2
• CSN2JAB1-containing signalosome subunit 2
• SGN2TR-interacting protein 15
• Signalosome subunit 2
• thyroid receptor interacting protein 15
• Thyroid receptor-interacting protein 15
• TRIP15TRIP-15

Background

COP9 signalosome is a conserved protein composed of eight subunits. Individual subunits of the complex have been linked to various signal transduction pathways leading to gene expression and cell cycle control. CSN2 is a transcriptional corepressor that encodes the second subunit of COP9 signalosome. CSN2 interacts with and regulates a subset of nuclear hormone receptors and is considered a novel repressor. It also plays a critical role in neuronal differentiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: COPS2
• Entrez:
  • 9318(Human)
• Uniprot:
  • NP_004227.1(Human)