Complement Factor H-related 1/CFHR1/CFHL1 Antibody [Alexa Fluor® 647]

• Applications: WB, IP
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 647

Complement Factor H-related 1/CFHR1/CFHL1 Antibody [Alexa Fluor® 647] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Complement Factor H-related 1/CFHR1
  Glu19-Ala328
  Accession # Q03591
• Specificity: Detects human Complement Factor H-related 1/CFHR1 in direct ELISAs and Western blots. In direct ELISAs, approximately 25% cross‑reactivity with recombinant human (rh) FHR2 is observed and approximately 15% cross-reactivity with rhFHR5
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

FHR1 (Complement Factor H-related protein 1) is a 43 kDa, secreted member of the factor H family of glycoproteins. It is produced by hepatocytes and circulates as two differentially glycosylated isoforms (37 kDa and 43 kDa). Mature human FHR1 is 312 amino acids (aa) in length. It contains five, approximately 60 aa SCRs (short consensus repeats/CCPs/SUSHI repeats) that basically constitute the entire molecule. FHR1 may play a role in lipoprotein complexes that bind PMNs to LPS. There is no reported rodent counterpart to FHR1. Over aa 19‑143 of the FHR1 precursor, human FHR2 and FHR5 show 98% and 86% aa identity, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.