Complement Factor H-related 1/CFHR1/CFHL1 Antibody (442127) [Alexa Fluor® 405]

• Applications: WB, IP
• Clone: 442127
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

Complement Factor H-related 1/CFHR1/CFHL1 Antibody (442127) [Alexa Fluor® 405] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Complement Factor H-related 1/CFHR1
  Glu19-Ala328
  Accession # Q03591
• Specificity: Detects human Complement Factor H-related 1/CFHR1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant human (rh) CFHR2 or rhCFHR5 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Complement factor H-related protein 1 (CFHR1) is a 43 kDa, secreted member of the factor H family of glycoproteins. It is produced by hepatocytes and circulates as two differentially glycosylated isoforms (37 kDa and 43 kDa). Mature human CFHR1 is 312 aa in length. It contains five approximately 60 aa SCRs (short consensus repeats/CCPs/SUSHI repeats) that basically constitute the entire molecule. CFHR1 may play a role in lipoprotein complexes that bind LPS to neutrophils. There is no reported rodent counterpart to CFHR1. Over aa 19‑143 of the CFHR1 precursor, human CFHR2 and CFHR5 show 98% and 86% aa identity, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.