Complement C6 Antibody (056B-214.2.4.2)

Product Discontinued

Complement C6 Antibody (056B-214.2.4.2) Summary

• Immunogen: Purified human C6
• Specificity: NB100-64337 recognizes complement component 6 (C6), a 104 kDa member of the complement C6/C7/C8/C9 family present in blood serum. The factor I modules of C6 bind the C-terminus of the C5b alpha-chain, anchoring the molecule to the membrane; they also binds complement component 7. This enables the formation of the C5b-7 precursor complex. C5b-7 then functions as a receptor for components C8 and C9 which form the complement membrane attack complex (MAC). Deficiency of C6 results in susceptibility to bacterial infection. NB100-64337 recognizes MAC.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: C6
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
• Control:

  Complement C6 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Borate buffered saline
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein A purified

Alternate Names for Complement C6 Antibody (056B-214.2.4.2)

• complement component 6
• complement component C6

Background

C6 is a component of complement cascade. It is involved in the formation of the lytic C5b-9m complex. People with C6 deficiency are prone to bacterial infection.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: C6
• Entrez:
  • 729(Human)
• Uniprot:
  • P13671(Human)