Complement C4 Antibody [HRP]

Product Discontinued

Complement C4 Antibody [HRP] Summary

• Immunogen: Purified human complement C4
• Specificity: This antibody recognises human Complement component 4 (C4). CD4 is a component of the classical complement pathway and is composed of three subunits (an alpha chain with an approximate Mw. of 96kDa, a beta chain with a Mw. of 75kDa and a gamma chain with a Mw. of 33kDa)
• Clonality: Polyclonal
• Host: Sheep
• Gene: C4A
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Frozen 1:50-1:200

Reactivity Notes

Human. Expected to react with Rat, Cat, and Rabbit based on sequence identity

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.01% Thimerosal
• Concentration: 1.0 mg/ml
• Purity: Protein G purified

Alternate Names for Complement C4 Antibody [HRP]

• C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
• C4
• complement component 4A (Rodgers blood group)
• RG

Background

C4 consists of three polypeptide chains (alpha, molecular weight 95 kDa, beta, molecular weight 75 kDa and gamma, molecular weight 33 kDa) and is usually present in serum at 200-600mg/L. It is a protein of the classical complement pathway. When activated by C1s, a peptide C4a is released and the generated C4b binds C2 which is in turn cleaved by C1s to produce the classical pathway C3 convertase, namely C4b2a. C4b also has opsonin activity and binds to macrophages and neutrophils via their CR1 receptor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: C4A