Common beta Chain Antibody (RM0112-42A7)

Product Discontinued

Common beta Chain Antibody (RM0112-42A7) Summary

• Immunogen: Mouse recombinant protein of the extracellular domain of IL-3 R Beta
• Specificity: This was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with mouse recombinant protein of the extracellular domain of IL-3 R Beta.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Rat
• Gene: CSF2RB
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:1000
• Application Notes: This antibody detects mouse IL-3R beta, but not IL-3R alpha in Western blotting.

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from 0.2 um filtered PBS
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein G purified
• Reconstitution Instructions: Reconstitute with sterilized PBS to a final concentration of 0.5 mg/ml.

Alternate Names for Common beta Chain Antibody (RM0112-42A7)

• beta, low-affinity
• CD131 antigen
• CD131
• CDw131
• colony stimulating factor 2 receptor, beta, low-affinity(granulocyte-macrophage)
• Common beta Chain
• CSF2RB
• cytokine receptor common subunit beta
• GM-CSF R beta
• GM-CSF/IL-3/IL-5 receptor common beta subunit
• GM-CSF/IL-3/IL-5 receptor common beta-chain
• IL-3 R beta
• IL3RB
• IL-5 R beta
• interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3receptor, beta (high affinity)

Background

IL3R common beta chain (IL3RB)is a member of the Ig superfamily and a type I transmembrane glycoprotein. The common beta subunit associates with the specific alpha subunits of IL3 receptor, IL5 receptor and GMCSF receptor to form high affinity receptors for these cytokines. These cytokine receptors are expressed by neutrophils, eosinophils, monocytes, endothelial cells, fibroblasts and hematopoietic progenitor cells and play a crucial role in growth/activation of eosinophils and in the inflammatory response.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CSF2RB
• Entrez:
  • 1439(Human)