Common beta Chain Products

Description

Interleukin-3 receptor (IL-3R) is a heterodimer cytokine composed of alpha chain and beta chain. IL-3R beta subunit (CD131, beta C) is a common shared beta chain of the receptor for granulocyte- macrophage colony-stimulating factor (GM-CSF) and IL-5 (1). While the beta chain can not bind to the ligand alone, but it is essential for high affinity ligand binding (2). The cytoplasmic portion of the beta chain contains the major domains necessary for ligand-induced proliferation (3). IL-3R beta is expressed in neutrophil, eosinophil, monocyte, and hematpoietic stem cells. A point mutation leading to defective IL-3R beta expression has been associated to Human pulmonary alveolar proteinosis (PAP), a rare cause of respiratory failure (4).

Bioinformatics

Entrez	1439 Human
Uniprot	AAH70085.1 Human NP_000386 Human P26954 Mouse P32927 Human
Product By Gene ID	1439
Alternate Names	beta, low-affinity CD131 antigen CD131 CDw131 colony stimulating factor 2 receptor, beta, low-affinity(granulocyte-macrophage) cytokine receptor common subunit beta GM-CSF/IL-3/IL-5 receptor common beta subunit GM-CSF/IL-3/IL-5 receptor common beta-chain IL3RB interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3receptor, beta (high affinity)

Research Areas for Common beta Chain

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific