Species: Hu
Applications: WB, Flow, Func, ICC/IF, IHC, IP, B/N
Host: Rabbit Monoclonal
Species: Hu
Applications: WB, Flow, CyTOF-ready
Host: Goat Polyclonal
Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: Bioactivity
Species: Hu
Applications: PAGE
Description
Interleukin-3 receptor (IL-3R) is a heterodimer cytokine composed of alpha chain and beta chain. IL-3R beta subunit (CD131, beta C) is a common shared beta chain of the receptor for granulocyte- macrophage colony-stimulating factor (GM-CSF) and IL-5 (1). While the beta chain can not bind to the ligand alone, but it is essential for high affinity ligand binding (2). The cytoplasmic portion of the beta chain contains the major domains necessary for ligand-induced proliferation (3). IL-3R beta is expressed in neutrophil, eosinophil, monocyte, and hematpoietic stem cells. A point mutation leading to defective IL-3R beta expression has been associated to Human pulmonary alveolar proteinosis (PAP), a rare cause of respiratory failure (4).
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Mouse
Human
|
| Product By Gene ID |
1439 |
| Alternate Names |
- beta, low-affinity
- CD131 antigen
- CD131
- CDw131
- colony stimulating factor 2 receptor, beta, low-affinity(granulocyte-macrophage)
- cytokine receptor common subunit beta
- GM-CSF/IL-3/IL-5 receptor common beta subunit
- GM-CSF/IL-3/IL-5 receptor common beta-chain
- IL3RB
- interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3receptor, beta (high affinity)
|
Research Areas for Common beta Chain
Find related products by research area and learn more about each of the different research areas below.
Phospho-Specific
![Binding Activity Common beta Chain [Unconjugated]](http://images.novusbio.com/fullsize2/Common_beta_Chain_9960CB_2079.jpg)
![SDS-PAGE Common beta Chain [Unconjugated]](http://images.novusbio.com/fullsize2/Common_beta_Chain_9960CB_2028.jpg)
