Collybistin/ARHGEF9 Antibody (809309) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 809309
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

Collybistin/ARHGEF9 Antibody (809309) [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human Collybistin/ARHGEF9
  Asn390-Lys516
  Accession # O43307
• Specificity: Detects human Collybistin/ARHGEF9 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Collybistin/ARHGEF9 Antibody (809309) [Alexa Fluor® 405]

• ARHGEF9
• Cdc42 guanine nucleotide exchange factor (GEF) 9
• Collybistin
• EIEE8
• hPEM-2 collybistin
• KIAA0424
• KIAA0424HPEM-2
• PEM-2 homolog
• PEM2
• PEM-2
• Rac/Cdc42 guanine nucleotide exchange factor 9
• rho guanine nucleotide exchange factor 9

Background

Collybistin, also known as ARHGEF9, is an approximately 60 kDa cytoplasmic guanine nucleotide exchange factor. It is expressed in the brain and is upregulated at the onset of neuronal differentiation. Collybistin associates with Neuroligin-2, Gephyrin, and GABA receptor subunits to form a complex which is required for GABAergic synaptogenesis as well as hippocampal synaptic plasticity. Mutations in Collybistin are associated with a variety of neurological disorders including epilepsy, anxiety, aggression, mental retardation, and hyperplexia. Human Collybistin contains an SH3 domain (aa 8-67), a DH domain (aa 103-287), and a Pleckstrin homology domain (aa 318-426). Within aa 390-516, human Collybistin shares 97% and 57% aa sequence identity with mouse and rat Collybistin, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.