Collybistin/ARHGEF9 Antibody (809309) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 809309
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

Collybistin/ARHGEF9 Antibody (809309) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human Collybistin/ARHGEF9 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Collybistin/ARHGEF9 Antibody (809309) [Alexa Fluor™ Plus 647]

• ARHGEF9
• Cdc42 guanine nucleotide exchange factor (GEF) 9
• Collybistin
• EIEE8
• hPEM-2 collybistin
• KIAA0424
• KIAA0424HPEM-2
• PEM-2 homolog
• PEM2
• PEM-2
• Rac/Cdc42 guanine nucleotide exchange factor 9
• rho guanine nucleotide exchange factor 9

Background

Collybistin, also known as ARHGEF9, is an approximately 60 kDa cytoplasmic guanine nucleotide exchange factor. It is expressed in the brain and is upregulated at the onset of neuronal differentiation. Collybistin associates with Neuroligin-2, Gephyrin, and GABA receptor subunits to form a complex which is required for GABAergic synaptogenesis as well as hippocampal synaptic plasticity. Mutations in Collybistin are associated with a variety of neurological disorders including epilepsy, anxiety, aggression, mental retardation, and hyperplexia. Human Collybistin contains an SH3 domain (aa 8-67), a DH domain (aa 103-287), and a Pleckstrin homology domain (aa 318-426). Within aa 390-516, human Collybistin shares 97% and 57% aa sequence identity with mouse and rat Collybistin, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.