Collagen VII Antibody (ICRF44) [Alexa Fluor® 488]

Product Discontinued

Collagen VII Antibody (ICRF44) [Alexa Fluor® 488] Summary

• Immunogen: Type VII Collagen non-collagenous domain 2 [LH24]
• Specificity: LH24 targets the basement membrane zone of keratinocytes, specifically Type VII Collagen non-collagenous domain 2. Type VII collagen and anchoring fibril deficiencies in skin biopsy samples were confirmed by immunofluorescence microscopy and immunoelectron microscopy using the LH24 antibody.
• Isotype: IgM
• Clonality: Monoclonal
• Host: Mouse
• Gene: COL7A1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Electron Microscopy
  • Immunofluorescence
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Affinity purified

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Collagen VII Antibody (ICRF44) [Alexa Fluor® 488]

• Collagen 7
• collagen alpha-1(VII) chain
• collagen VII, alpha-1 polypeptide
• collagen, type VII, alpha 1
• Collagen-7
• EBD1
• EBDCT
• EBR1
• epidermolysis bullosa, dystrophic, dominant and recessive
• LC collagen
• long chain collagen
• Long-chain collagen

Background

Type VII collagen fibrils are composed of three identical alpha collagen chains. It's location is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in the collagen V11 gene are associated with all forms of dystrophic epidermolysis bullosa.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: COL7A1