CNP/NPPC Antibody (347625) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 347625
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 405

CNP/NPPC Antibody (347625) [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human CNP
  Lys24-Cys126
  Accession # P23582
• Specificity: Detects human CNP Propeptide in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-react with recombinant human (rh) ANP precursor or rhBNP precursor is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CNP/NPPC Antibody (347625) [Alexa Fluor® 405]

• CNP
• CNP2
• C-type natriuretic peptide
• natriuretic peptide C
• natriuretic peptide precursor C
• NPPC

Background

CNP belongs to the natriuretic peptide family and functions in an autocrine or paracrine fashion. CNP interacts with the GC-B/NPR-B receptor to promote vasorelaxation, vascular remodeling, and the growth and differentiation of bone and neural tissue. CNP is synthesized as a prohormone that is cleaved intracellularly by furin, yielding a 49 aa propeptide (aa 24‑72) and a 53 aa mature peptide (aa 74‑126). Additional cleavage of the mature peptide generates 29 aa (aa 98‑126) and 22 aa (aa 105‑126) peptides, which have comparable activity in some assays. The human CNP prohormone shares 91% and 94% aa sequence identity with mouse and rat, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.