CLEC-2/CLEC-1B Antibody

Western Blot: CLEC1B Antibody [NB100-93458] - (1ug/ml) staining of human kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

• Reactivity: Hu
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

CLEC-2/CLEC-1B Antibody Summary

• Immunogen: Peptide with sequence KGHKCSPCDTNWRY corresponding to internal region according to NP_001092901.1, NP_057593.3.
• Epitope: KGHKCSPCDTNWRY
• Specificity: This antibody is expected to recognize both reported isoforms (NP_001092901.1; NP_057593.3)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: CLEC1B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:1000
  • Western Blot 1 - 3 ug/ml
• Application Notes: WB: Approx. 28 kDa band observed in human bone marrow and human kidney lysates (calculated MW of 26.6 kDa band according to NP_001092901.1).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for CLEC-2/CLEC-1B Antibody

• 1810061I13Rik
• CLEC1B
• CLEC2
• CLEC-2
• CLEC2B
• CLEC2PRO1384
• C-type lectin domain family 1 member B
• C-type lectin domain family 1, member B
• C-type lectin-like receptor 2
• C-type lectin-like receptor-2
• QDED721

Background

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CLEC-2/CLEC-1B Antibody (NB100-93458)(1)

Publication using NB100-93458

• Suzuki-Inoue K, Kato Y, Inoue O et al. Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells. J Biol Chem 2007-09-07 [PMID: 17616532]

Bioinformatics

• Gene Symbol: CLEC1B
• Entrez:
  • 51266(Human)
• Uniprot:
  • NP_001092901.1(Human)