Chondromodulin-1/LECT1 Antibody (394002) [Unconjugated]

• Reactivity: Hu
• Applications: WB
• Clone: 394002
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: LYOPH

Chondromodulin-1/LECT1 Antibody (394002) [Unconjugated] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Chondromodulin‑1 mature chain
  Glu215-Val333
  Accession # NP_001011705.1
• Specificity: Detects human Chondromodulin‑1 in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: LECT1
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Chondromodulin-1/LECT1 Antibody (394002) [Unconjugated]

• BRICD3
• BRICHOS domain containing 3
• ChM-1
• CHM1chondromodulin I
• CHMI
• ChM-I
• chondromodulin
• Chondromodulin1
• Chondromodulin-1
• chondromodulin-I
• LECT1
• leukocyte cell derived chemotaxin 1
• Leukocyte cell-derived chemotaxin 1
• multiple myeloma tumor suppressor 1
• MYETS1

Background

Chondromodulin-1 (ChM-1), also known as Lect1, is a type II transmembrane protein that is cleaved intracellularly resulting in the secretion of a 25 kDa molecule. ChM-1 is expressed in avascular cartilage, cardiac valves, and the eye. The antiangiogenic properties of ChM-1 can block tumor progression and the pathological vascularization of cardiac valves. Human ChM-1 shares 89%‑92% aa sequence identity with bovine, mouse, rabbit, and rat ChM-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Chondromodulin-1/LECT1 Antibody (MAB41681)(2)

Publications using MAB41681

• John Danias, Rosana Gerometta, Yongchao Ge, Lizhen Ren, Lampros Panagis, Thomas W. Mittag et al. Gene Expression Changes in Steroid-Induced IOP Elevation in Bovine Trabecular Meshwork Investigative Opthalmology & Visual Science 2011-11-07 [PMID: 21980000]
• Stagos D, Zhou H, Ross D, Vasiliou V 4-HNE inhibits tube formation and up-regulates chondromodulin-I in human endothelial cells. Biochem. Biophys. Res. Commun., 2008-12-03;379(3):654-8. 2008-12-03 [PMID: 19056352] (Western Blot, Human)

Bioinformatics

• Gene Symbol: LECT1
• Uniprot:
  • NP_001011705.1()