Chondromodulin-1/LECT1 Antibody (394002) [FITC]

• Reactivity: Hu
• Applications: WB
• Clone: 394002
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: FITC

Chondromodulin-1/LECT1 Antibody (394002) [FITC] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Chondromodulin‑1 mature chain
  Glu215-Val333
  Accession # NP_001011705.1
• Specificity: Detects human Chondromodulin‑1 in direct ELISAs and Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: LECT1
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for Chondromodulin-1/LECT1 Antibody (394002) [FITC]

• BRICD3
• BRICHOS domain containing 3
• ChM-1
• CHM1chondromodulin I
• CHMI
• CHM-I
• chondromodulin
• Chondromodulin1
• Chondromodulin-1
• chondromodulin-I
• LECT1
• leukocyte cell derived chemotaxin 1
• Leukocyte cell-derived chemotaxin 1
• multiple myeloma tumor suppressor 1
• MYETS1

Background

LECT1 encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LECT1