Chk2 Antibody (235303) [Alexa Fluor® 350]

• Applications: WB, IHC
• Clone: 235303
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 350

Chk2 Antibody (235303) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant mouse Chk2
  Met1-Ala234
  Accession # Q9Z265
• Specificity: Detects endogenous mouse Chk2 in Western blots.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Checkpoint kinase 2 (Chk2) is a critical protein kinase involved in the cellular response to DNA damage. Chk2 is a target of the ATM protein kinase, and can phoshorylate multiple proteins, including Cdc25A and p53, to activate the G₁/S cell cycle checkpoint. Patients with Li-Fraumeni syndrome, a cancer-prone familial disorder, may have a mutation in the chk2 or p53 genes, which suggests that Chk2 also functions as a tumor suppressor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.