Chk2 Products

Antibodies
Chk2 Antibody (1238H) [Unconj ...
Chk2 Antibody (1238H) [Unconjugated]
MAB1626
Species: Hu
Applications: WB, ICC
Host: Rabbit Monoclonal
Chk2 Antibody (5C4)
Chk2 Antibody (5C4)
Species: Hu, Ca, Mk
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Host: Mouse Monoclonal
Chk2 [p thr68] Antibody [Unco ...
Chk2 [p thr68] Antibody [Unconjuga...
AF1626
Species: Hu
Applications: WB, ICC
Host: Rabbit Polyclonal
Antibody Pairs
Chk2 Antibody Pair
Chk2 Antibody Pair
H00011200-AP11
Species: Hu
Applications: S-ELISA
Chk2 Antibody Pair
Chk2 Antibody Pair
H00011200-PW1
Species: Hu
Applications: WB, IP
Kits
Lysates
Chk2 Overexpression Lysate (D ...
Chk2 Overexpression Lysate (Denatu...
H00011200-T01
Species: Hu
Applications: WB
Chk2 Overexpression Lysate (N ...
Chk2 Overexpression Lysate (Native)
NBP2-10753
Applications: WB
Chk2 Overexpression Lysate (N ...
Chk2 Overexpression Lysate (Native)
NBL1-09147
Applications: WB
Proteins
Chk2 Recombinant Protein
Chk2 Recombinant Protein
H00011200-P01
Species: Hu
Applications: WB, ELISA, PA
Chk2 Recombinant Protein Anti ...
Chk2 Recombinant Protein Antigen
NBP1-90024PEP
Species: Hu
Applications: AC
Chk2 Recombinant Protein
Chk2 Recombinant Protein
H00011200-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Chk2 RNAi
Chk2 RNAi
H00011200-R09
Species: Hu
Applications: RNAi, RNAi SP
Chk2 RNAi
Chk2 RNAi
H00011200-R07
Species: Hu
Applications: RNAi, RNAi SP
Chk2 RNAi
Chk2 RNAi
H00011200-R08
Species: Hu
Applications: RNAi, RNAi SP

Description

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 11200
Alternate Names
  • EC 2.7.11
  • EC 2.7.11.1
  • S.pombe) homolog
  • CHK2 checkpoint homolog (S. pombe)

Research Areas for Chk2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Breast Cancer
Cancer
Cell Cycle and Replication
Checkpoint signaling
Core ESC-Like Genes
DNA Double Strand Break Repair
DNA Repair
Phospho-Specific
Stem Cell Markers

PTMs for Chk2

Learn more about PTMs related to Chk2.

Phosphorylation
Methylation
Acetylation

Bioinformatics Tool for Chk2

Discover related pathways, diseases and genes to Chk2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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