ChemR23/CMKLR1 Antibody

Product Discontinued

ChemR23/CMKLR1 Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 216-265 of Human MChemR23.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CMKLR1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000
• Application Notes: Western blot (WB) analyzes of ChemR23 (R249) pAb in extracts from Jurkat cells
• Theoretical MW: 42 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for ChemR23/CMKLR1 Antibody

• CHEMERINR
• chemokine receptor-like 1
• chemokine-like receptor 1
• ChemR23
• cmklr1
• Dez
• Gpcr27
• G-protein coupled receptor ChemR23
• G-protein coupled receptor DEZ
• MGC126105
• MGC126106
• orphan G-protein coupled receptor, Dez

Background

The C-X3-C chemokine family is characterized by two cysteines separated by three amino acid residues. Fractalkine is a member of this chemokine family that binds CX3CR1, previously named V28, and chemokine beta receptor-like 1 (CMKBRL1) with high affinity, to induce either leukocyte adhesion and migration or chemotactic functions. CX3CR1 functions with CD4 as a co-receptor for the HIV-1 virus envelope protein, and patients homozygous for a variant haplotype of CX3CR1 progress to AIDS more rapidly than those with other haplotypes. Chemokine receptor-like 1 (also designated G protein-coupled receptor DEZ or ChemR23) belongs to the G protein-coupled receptor 1 family. It is an integral membrane protein functioning as a receptor, possibly a chemotactic peptide receptor. It also acts as a co-receptor for various SIV strains and for a primary HIV-1 strain. ChemR23 is highly expressed in developing osseous and cartilaginous tissue, brain, kidney, gastrointestinal tissues and myeloid tissue, as well as in adult parathyroid glands.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CMKLR1
• Entrez:
  • 1240(Human)
  • 14747(Mouse)
  • 60669(Rat)
• Uniprot:
  • Q99788(Human)