CDK5 Activator 1 Antibody [mFluor Violet 610 SE]

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: mFluor Violet 610 SE

CDK5 Activator 1 Antibody [mFluor Violet 610 SE] Summary

• Immunogen: E. coli-derived recombinant human CDK5 Activator 1
  Gln100-Arg307
  Accession # Q15078
• Specificity: Detects human CDK5 Activator 1 in direct ELISAs.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: CDK5R1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for CDK5 Activator 1 Antibody [mFluor Violet 610 SE]

• CDK5 Activator 1
• CDK5P35
• CDK5R
• CDK5R1
• cyclin-dependent kinase 5 activator 1
• Cyclin-dependent kinase 5 regulatory subunit 1
• cyclin-dependent kinase 5, regulatory subunit 1 (p35)
• MGC33831
• NCK5A
• Neuronal CDK5 Activator
• p23
• p25
• p35
• p35nck5a
• regulatory partner for CDK5 kinase
• tau protein kinase II 23kDa subunit
• TPKII Regulatory Subunit

Background

The baculoviruses are a large, diverse family of DNA viruses that have evolved a number of mechanisms to manipulate thier insect hosts. One of these is the ability to regulate apoptosis during infection by expressing proteins that can inhibit caspase activation, including the caspase inhibitor p35 and the inhibitor of apoptosis (IAP) proteins (reviewed in Clem, 2005; Clarke and Clem, 2003; and Iller, 1997). The p35 baculovirus protein strongly inhibits caspase enzymatic activity, and is the the most broadly acting caspase inhibitor protein known. p35 baculovirus forms essentially irreversible complexes with its target caspases in a process that is accompanied by the cleavage of p35, generating two fragments of approximately 10 kDa and 25 kDa. These cleavage fragments remain associated with caspases and thereby block caspase activity. The ability of p35 to inhibit caspases along with the central role of caspases in the apoptotic process enables p35 baculovirus to block apoptosis in a phylogentically broad range of cells, and in response to a wide variety of apoptotic induction signals. For example, over expression of p35 in mammalian, insect, and nematode cells results in resistance to apoptosis. IMG-5740 recognizes p35 baculovirus; p35 baculovirus migrates at ~35 kDa on SDS-PAGE.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CDK5R1