CDK5 Activator 1 Products

Antibodies
CDK5 Activator 1 Antibody
CDK5 Activator 1 Antibody
AF7250
Species: Hu
Applications: IHC
Host: Sheep Polyclonal
CDK5 Activator 1 Antibody (73 ...
CDK5 Activator 1 Antibody (739304)
MAB7357
Species: Hu
Applications: WB
Host: Mouse Monoclonal
CDK5 Activator 1 Antibody (4G ...
CDK5 Activator 1 Antibody (4G11)
H00008851-M01
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Lysates
CDK5 Activator 1 Overexpressi ...
CDK5 Activator 1 Overexpression Ly...
NBL1-09041
Applications: WB
Proteins
CDK5 Activator 1 Recombinant ...
CDK5 Activator 1 Recombinant Prote...
NBP2-55112PEP
Species: Hu
Applications: B/N, Ctrl
Recombinant Human CDK5 Activa ...
Recombinant Human CDK5 Activator 1...
H00008851-Q01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human CDK5 Activa ...
Recombinant Human CDK5 Activator 1...
H00008851-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
CDK5 Activator 1 RNAi
CDK5 Activator 1 RNAi
H00008851-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

The baculoviruses are a large, diverse family of DNA viruses that have evolved a number of mechanisms to manipulate thier insect hosts. One of these is the ability to regulate apoptosis during infection by expressing proteins that can inhibit caspase activation, including the caspase inhibitor p35 and the inhibitor of apoptosis (IAP) proteins (reviewed in Clem, 2005; Clarke and Clem, 2003; and Iller, 1997). The p35 baculovirus protein strongly inhibits caspase enzymatic activity, and is the the most broadly acting caspase inhibitor protein known. p35 baculovirus forms essentially irreversible complexes with its target caspases in a process that is accompanied by the cleavage of p35, generating two fragments of approximately 10 kDa and 25 kDa. These cleavage fragments remain associated with caspases and thereby block caspase activity. The ability of p35 to inhibit caspases along with the central role of caspases in the apoptotic process enables p35 baculovirus to block apoptosis in a phylogentically broad range of cells, and in response to a wide variety of apoptotic induction signals. For example, over expression of p35 in mammalian, insect, and nematode cells results in resistance to apoptosis. IMG-5740 recognizes p35 baculovirus; p35 baculovirus migrates at ~35 kDa on SDS-PAGE.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 8851
Alternate Names
  • CDK5P35
  • tau protein kinase II 23kDa subunit
  • Nck5a
  • regulatory partner for CDK5 kinase
  • TPKII regulatory subunit
  • p35
  • CDK5 activator 1
  • p25
  • NCK5A
  • p23
  • CDK5R
  • neuronal CDK5 activator
  • Cyclin-dependent kinase 5 regulatory subunit 1
  • cyclin-dependent kinase 5 activator 1
  • p35nck5a
  • MGC33831
  • cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Research Areas for CDK5 Activator 1

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Signal Transduction

PTMs for CDK5 Activator 1

Learn more about PTMs related to CDK5 Activator 1.

Phosphorylation
Cleavage

Bioinformatics Tool for CDK5 Activator 1

Discover related pathways, diseases and genes to CDK5 Activator 1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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