CDC2L2 Antibody [Biotin]

Western Blot: CDC2L2 Antibody [Biotin] [NBP1-71798] - Whole cell lysate from HeLa (50 and 15 ug). Antibody used at 1.0 ug/ml.

Product Discontinued

CDC2L2 Antibody [Biotin] Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residues 730 and the C-terminus (residue 780) of human Cell Division Cycle 2-like 2 using the numbering given in SwissProt entry Q9UQ88 (GeneID 985).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CDK11A
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:1000-1:5000
• Readout System:
  • Streptavidin Native Protein NBP2-29367
  • Streptavidin Native Protein NBP2-29370
  • Streptavidin Native Protein NBP2-29371

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS and 0.2% BSA
• Preservative: 0.09% Sodium Azide
• Concentration: LYOPH
• Purity: Immunogen affinity purified
• Reconstitution Instructions: Reconstitute with 0.1 ml deionized water.

Alternate Names for CDC2L2 Antibody [Biotin]

• CDC2L2
• CDC2L3
• CDK11A
• CDK11-p110
• CDK11-p58
• cyclin-dependent kinase 11A
• PITSLRE protein kinase beta
• PITSLREB

Background

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CDK11A