Cdc20 Antibody (AR12) [DyLight 755]

• Reactivity: Hu
• Applications: Flow, ICC/IF, IHC, CyTOF-ready
• Clone: AR12
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 755

Cdc20 Antibody (AR12) [DyLight 755] Summary

• Description: This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
• Immunogen: Urea-denatured His6 Cdc20 human recombinant protein (Uniprot: Q12834)
• Localization: Cytoplasmic
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: CDC20
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Cdc20 Antibody (AR12) [DyLight 755]

• CDC20 cell division cycle 20 homolog (S. cerevisiae)
• CDC20 cell division cycle 20 homolog
• Cdc20
• cell division cycle 20 homolog (S. cerevisiae)
• cell division cycle protein 20 homolog
• MGC102824
• p55CDC
• p55CDCS. cerevisiae, homolog)

Background

CDC20 is a WD repeat containing cell cycle-regulator that binds to and activates the ubiquitin-ligase activity of the APC/c (anaphase-promoting complex/cyclosome). APC/c ubiquitinating activity is responsible for the degradation of securin and cyclin B that prompts the onset of anaphase and exit from mitosis. CDC20 has also been reported to form a complex with histone deacetylases and can function as a transcriptional repressor involved in cell cycle arrest. As a regulator of APC/c activity, CDC20 plays a key role in the spindle-assembly checkpoint.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CDC20