CD57 Antibody (1088014) [Alexa Fluor® 532]

• Reactivity: Hu
• Clone: 1088014
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

CD57 Antibody (1088014) [Alexa Fluor® 532] Summary

• Immunogen: Whole Cell
  Accession # Q9P2W7
• Specificity: Detects the CD57 carbohydrate epitope in Human PBMCs
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CD57 Antibody (1088014) [Alexa Fluor® 532]

• CD57
• HNK1
• HNK-1
• Human Natural Killer-1
• L2
• LEU7
• LEU-7

Background

CD57 is a glycoprotein with a molecular weight of approximately 100 kDa, classified within the group of adhesion molecules. It plays a significant role in immune regulation and cellular interactions, particularly influencing the functioning of natural killer (NK) cells and certain T-cells. CD57 is heavily involved in the biological processes of cytotoxic activity and immune response modulation. Altered levels of CD57 expression have been associated with several pathological conditions, including chronic infections, autoimmune diseases, and various malignancies. Crucially, CD57 serves as a key biomarker for immune senescence and the monitoring of NK cell and T-cell activities in diseases such as HIV and cancer.

1. Kared H, Martelli S, Ng TP, Pender SL, Larbi A. CD57 in human natural killer cells and T-lymphocytes. Cancer Immunol Immunother. 2016 Apr;65(4):441-52. doi: 10.1007/s00262-016-1803-z. Epub 2016 Feb 5. PMID: 26850637; PMCID: PMC11029668. 

2. Elias Junior E, Gubert VT, Bonin-Jacob CM, Puga MAM, Gouveia CG, Sichinel AH, Tozetti IA. CD57 T cells associated with immunosenescence in adults living with HIV or AIDS. Immunology. 2024 Jan;171(1):146-153. doi: 10.1111/imm.13707. Epub 2023 Oct 25. PMID: 37880915. 

3. Lian J, Yue Y, Yu W, Zhang Y. Immunosenescence: a key player in cancer development. J Hematol Oncol. 2020 Nov 10;13(1):151. doi: 10.1186/s13045-020-00986-z. Erratum in: J Hematol Oncol. 2025 Mar 5;18(1):25. doi: 10.1186/s13045-025-01682-6. PMID: 33168037; PMCID: PMC7653700.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q9P2W7()