CD35 Antibody (E11) [Alexa Fluor® 350]

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Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications ELISA
Clone
E11
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 350

CD35 Antibody (E11) [Alexa Fluor® 350] Summary

Immunogen
Intact human monocytes were used as immunogen to generate the CD35 antibody (Hogg et al, 1984).
Localization
Cell surface
Marker
Follicular Dendritic Cell Marker
Specificity
Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1)/CD35. This MAb is specific for a site in CR1 that is distal from the C3b-binding site, so that it is unable to block CR1 activity. This MAb is highly specific to CR1 and shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21+/CD35+/CD1a-. This MAb labels follicular dendritic cells and follicular dendritic cell sarcoma.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CR1
Purity
Protein G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • ELISA
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Baboon, Cynomolgus Monkey, Rhesus Monkey.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes



Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for CD35 Antibody (E11) [Alexa Fluor® 350]

  • C3BR
  • CD35
  • complement component (3b/4b) receptor 1 (Knops blood group)
  • CR1
  • KN

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-33080AF350
Alexa Fluor 405 NBP2-33080AF405
Alexa Fluor 488 NBP2-33080AF488
Alexa Fluor 532 NBP2-33080AF532
Alexa Fluor 594 NBP2-33080AF594
Alexa Fluor 647 NBP2-33080AF647
Alexa Fluor 700 NBP2-33080AF700
Alexa Fluor 750 NBP2-33080AF750
Biotin NBP2-33080B
DyLight 350 NBP2-33080UV
DyLight 405 NBP2-33080V
DyLight 488 NBP2-33080G
DyLight 550 NBP2-33080R
DyLight 594 NBP2-33080DL594
DyLight 650 NBP2-33080C
DyLight 680 NBP2-33080FR
DyLight 755 NBP2-33080IR
FITC NBP2-33080F
HRP NBP2-33080H

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Contact Information

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Product PDFs

Calculators

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Bioinformatics

Gene Symbol CR1