CD3 epsilon Antibody (145-2C11) [Alexa Fluor® 488] Summary
H-2Kb-specific mouse cytotoxic T-lymphocyte
Detects mouse CD3 epsilon. Binds to lymphocytes from all mouse strains tested and does not react with cells from rats, rabbits, miniature swine, or hamsters.1 Binds to the CD3 epsilon -chain present on T-lymphocyes and thymocytes. Its binding has been characterized with respect to several other monoclonal anti-CD3 antibodies.3,4
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Flow Cytometry 0.25-1 ug/10^6 cells
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.
Packaging, Storage & Formulations
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for CD3 epsilon Antibody (145-2C11) [Alexa Fluor® 488]
- CD3 epsilon
- CD3e antigen
- CD3e antigen, epsilon polypeptide (TiT3 complex)
- CD3e molecule, epsilon (CD3-TCR complex)
- T-cell antigen receptor complex, epsilon subunit of T3
- T-cell surface antigen T3/Leu-4 epsilon chain
- T-cell surface glycoprotein CD3 epsilon chain
CD3 is composed of five different polypeptides ranging from 16‑28 kDa that are associated with the T cell receptor (TCR) complex and serve as its signal transducing element. The CD3/TCR complex is expressed on T cells and thymocytes. Binding of immobilized anti-CD3 can cause T cell activation that leads to any of several consequences, depending on the conditions. Activation by anti-CD3 in the presence of IL 2 has been reported to induce cell death, apparently via apoptosis.4
The antibody can be used to induce cytolytic activity against non-specific targets and also to block TCR-mediated cytolytic killing.1
145-2C11 has been used in a variety of studies concerned with allograft rejection and graft-vs host reaction in mice.6, 7
- Leo, O. et al. (1987) Proc. Natl. Acad. Sci. USA 84:1374.
- Portoles, P. et al. (1989) J. Immunol. 142:4169.
- Coulie, P.G. et al. (1991) Eur. J. Immunol. 21:1703.
- Ucker, D.S. J. Meyers and P.S. Obermiller. (1992) J. Immunol. 149:1583.
- Small, M. et al. (1994) J. Immunol. Meth. 167:103.
- Alegre, M.L. et al. (1991) J. Immunol. 146:1184.
- Hendrickson, M. et al. (1995) Transplantation 60:828.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
Customers Who Viewed This Item Also Viewed...
Species: Mu, Rt
Applications: Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Cell Depl, CyTOF-ready, InhibTFunc
Species: Hu, Mu, Rt, Ca, Rb
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P
Applications: Flow, IHC, IHC-Fr, IP
Applications: WB, Simple Western, IHC, IHC-P
Applications: Simple Western, Flow, ICC/IF, IHC, IHC-P
Species: Hu, Po
Applications: Flow, IHC, IHC-Fr, IF
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Flow-IC
Applications: Flow, IHC, IP, CompCytotox, CyTOF-ready, ICC, Tstim
Applications: WB, ICC
Species: Hu, Mu, Rt
Applications: WB, Flow, Func, ICC/IF, IHC, IHC-Fr, IHC-P, IP, In vitro, In vivo, CyTOF-ready
Species: Hu, Rt, Ze
Applications: WB, Simple Western, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Flow-CS
Species: Hu, Mu, Rt
Applications: WB, IHC, IP
Applications: WB, Flow, IHC, IHC-P, IP, Flow-CS
Publications for CD3 epsilon Antibody (FAB484G) (0)
There are no publications for CD3 epsilon Antibody (FAB484G).
By submitting your publication information earn gift cards and discounts for future purchases.
Reviews for CD3 epsilon Antibody (FAB484G) (0)
There are no reviews for CD3 epsilon Antibody (FAB484G).
By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
- Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
- Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
FAQs for CD3 epsilon Antibody (FAB484G) (0)
Other Available Formats
Additional CD3 epsilon Products
Bioinformatics Tool for CD3 epsilon Antibody (FAB484G)
Discover related pathways, diseases and genes to CD3 epsilon Antibody (FAB484G). Need help?
Read the Bioinformatics Tool Guide
for instructions on using this tool.
Blogs on CD3 epsilon