CD3 epsilon Antibody (145-2C11) [Alexa Fluor® 488]


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Product Details

Reactivity MuSpecies Glossary
Applications Flow
Alexa Fluor 488
Please see the vial label for concentration. If unlisted please contact technical services.

CD3 epsilon Antibody (145-2C11) [Alexa Fluor® 488] Summary

H-2Kb-specific mouse cytotoxic T-lymphocyte
Detects mouse CD3 epsilon. Binds to lymphocytes from all mouse strains tested and does not react with cells from rats, rabbits, miniature swine, or hamsters.1 Binds to the CD3 epsilon -chain present on T-lymphocyes and thymocytes. Its binding has been characterized with respect to several other monoclonal anti-CD3 antibodies.3,4
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  • Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CD3 epsilon Antibody (145-2C11) [Alexa Fluor® 488]

  • CD3 epsilon
  • CD3e antigen
  • CD3e antigen, epsilon polypeptide (TiT3 complex)
  • CD3e molecule, epsilon (CD3-TCR complex)
  • CD3e
  • CD3-epsilon
  • FLJ18683
  • T3E
  • T-cell antigen receptor complex, epsilon subunit of T3
  • T-cell surface antigen T3/Leu-4 epsilon chain
  • T-cell surface glycoprotein CD3 epsilon chain
  • TCRE


CD3 is composed of five different polypeptides ranging from 16‑28 kDa that are associated with the T cell receptor (TCR) complex and serve as its signal transducing element. The CD3/TCR complex is expressed on T cells and thymocytes. Binding of immobilized anti-CD3 can cause T cell activation that leads to any of several consequences, depending on the conditions. Activation by anti-CD3 in the presence of IL 2 has been reported to induce cell death, apparently via apoptosis.4 The antibody can be used to induce cytolytic activity against non-specific targets and also to block TCR-mediated cytolytic killing.1 145-2C11 has been used in a variety of studies concerned with allograft rejection and graft-vs host reaction in mice.6, 7
  1. Leo, O. et al. (1987) Proc. Natl. Acad. Sci. USA 84:1374.
  2. Portoles, P. et al. (1989) J. Immunol. 142:4169.
  3. Coulie, P.G. et al. (1991) Eur. J. Immunol. 21:1703.
  4. Ucker, D.S. J. Meyers and P.S. Obermiller. (1992) J. Immunol. 149:1583.
  5. Small, M. et al. (1994) J. Immunol. Meth. 167:103.
  6. Alegre, M.L. et al. (1991) J. Immunol. 146:1184.
  7. Hendrickson, M. et al. (1995) Transplantation 60:828.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gene Symbol Cd247