CD27 Ligand/TNFSF7/CD70 Antibody (BU69)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC-Fr, IP, ICC/IF
Clone
BU69
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.2 mg/ml

Order Details

CD27 Ligand/TNFSF7/CD70 Antibody (BU69) Summary

Immunogen
Human WM-1 (Waldenstrom s macroglobulinemia) cell line
Localization
Cell Surface
Marker
Activated T- & B-Lymphocyte Marker
Specificity
It recognizes a protein of 30kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. This MAb blocks the interaction between CD27 and CD70, and has been shown to inhibit T cell proliferation induced by dendritic cells.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CD70
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml
  • Immunohistochemistry-Frozen 0.5 - 1 ug/ml
  • Immunoprecipitation 0.5 - 1 ug/500ug Protein Lysate
  • Immunofluorescence 0.5 - 1.0 ug/ml
Application Notes
Hu-chromosome location: 19p13
; Inhibits T cell proliferation induced by dendritic cells Order Ab without Azide; Immunohistochemistry-Frozen 0.5 - 1 ug/ml for 30 minutes at RT
Theoretical MW
30 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
10mM PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.2 mg/ml
Purity
Protein A or G purified

Alternate Names for CD27 Ligand/TNFSF7/CD70 Antibody (BU69)

  • CD27 Ligand
  • CD27-L
  • CD27LCD27 ligand
  • CD27LG
  • CD70 molecule
  • CD70
  • Ki-24 antigen
  • surface antigen CD70
  • TNFSF7
  • TNFSF7CD70 antigen
  • tumor necrosis factor (ligand) superfamily, member 7
  • Tumor necrosis factor ligand superfamily member 7

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics Tool for CD27 Ligand/TNFSF7/CD70 Antibody (NBP2-44545)

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Diseases for CD27 Ligand/TNFSF7/CD70 Antibody (NBP2-44545)

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Bioinformatics

Gene Symbol CD70