CD20 Antibody (MS4A1/3410) [DyLight 680]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clone
MS4A1/3410
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 680

Order Details

CD20 Antibody (MS4A1/3410) [DyLight 680] Summary

Immunogen
Recombinant fragment (around aa 213-297) of human MS4A1 protein (exact sequence is proprietary)
Localization
Cell Surface
Specificity
Recognizes a protein of 30-33kDa, which is identified as CD20. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre-B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This MAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkin's disease, particularly of lymphocyte predominant type.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
MS4A1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for CD20 Antibody (MS4A1/3410) [DyLight 680]

  • B1
  • B-lymphocyte antigen CD20
  • B-lymphocyte cell-surface antigen B1
  • B-lymphocyte surface antigen B1
  • Bp35
  • Bp35MGC3969
  • CD20 antigen
  • CD20 receptor
  • CD20
  • CD20S7
  • CVID5
  • LEU-16
  • Leukocyte surface antigen Leu-16
  • Ly-44
  • Membrane-spanning 4-domains subfamily A member 1
  • membrane-spanning 4-domains, subfamily A, member 1
  • MS4A1
  • MS4A2
  • S7

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-78052AF350
Alexa Fluor 405 NBP2-78052AF405
Alexa Fluor 488 NBP2-78052AF488
Alexa Fluor 532 NBP2-78052AF532
Alexa Fluor 594 NBP2-78052AF594
Alexa Fluor 647 NBP2-78052AF647
Alexa Fluor 700 NBP2-78052AF700
Alexa Fluor 750 NBP2-78052AF750
Biotin NBP2-78052B
DyLight 350 NBP2-78052UV
DyLight 405 NBP2-78052V
DyLight 488 NBP2-78052G
DyLight 550 NBP2-78052R
DyLight 594 NBP2-78052DL594
DyLight 650 NBP2-78052C
DyLight 680 NBP2-78052FR
DyLight 755 NBP2-78052IR
FITC NBP2-78052F
HRP NBP2-78052H
Janelia Fluor 549 NBP2-78052JF549
Janelia Fluor 646 NBP2-78052JF646

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Antigen-loss relapse after successful CAR-T therapy; What do we do now?
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Bioinformatics

Gene Symbol MS4A1