CD161/NK1.1 Antibody (PK136) [Alexa Fluor™ Plus 594]

• Reactivity: Mu
• Clone: PK136
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 594

CD161/NK1.1 Antibody (PK136) [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects mouse CD161/NK1.1 in Flow Cytometry.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CD161/NK1.1 Antibody (PK136) [Alexa Fluor™ Plus 594]

• CD161 antigen
• CD161
• CD161/NK1.1
• CD161c
• CLEC5BC-type lectin domain family 5 member B
• HNKR-P1a
• killer cell lectin-like receptor subfamily B member 1
• killer cell lectin-like receptor subfamily B, member 1
• Klrb1c
• Ly55c
• Ly-59
• Natural killer cell surface protein P1A
• NKR-P1
• NKR-P1AMGC138614
• NKRP1ANKR

Background

NK-1.1 surface antigen is encoded by the NKR-P1B/NKR-P1C gene, also known as CD161b/CD161c and Ly-55. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN- gamma production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers. The PK136 antibody has been reported to deplete NK cells, induce redirected lysis, block NK cell function, and induce NK cell proliferation.

 

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.