CD161/NK1.1 Products

Description

NK-1.1 surface antigen is encoded by the NKR-P1B/NKR-P1C gene, also known as CD161b/CD161c and Ly-55. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN- gamma production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers. The PK136 antibody has been reported to deplete NK cells, induce redirected lysis, block NK cell function, and induce NK cell proliferation.

Bioinformatics

Product By Gene ID	17059
Alternate Names	CD161c CD161 antigen hNKR-P1A HNKR-P1a NKR-P1 killer cell lectin-like receptor subfamily B member 1 CD161 NKRP1ANKR NKR-P1AMGC138614 CLEC5BC-type lectin domain family 5 member B Natural killer cell surface protein P1A killer cell lectin-like receptor subfamily B, member 1

Diseases related to CD161/NK1.1

Discover more about diseases related to CD161/NK1.1.

Neoplasms
Inflammation
Autoimmune Reaction
Neoplasm Metastasis
Malignant Neoplasms
Autoimmune Diseases
Melanoma, Experimental
Melanoma
Neoplasms, Experimental
Tissue Adhesions
Salmonella Infections
Lymphopenia
Colitis
Graft-vs-host Disease
Listeriosis
B16 Malignant Melanoma
Immunologic Deficiency Syndromes
Infective Disorder
Salmonella Infections, Animal

Pathways for CD161/NK1.1

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Immune Response
Cell Development
Cytokine Production
Cell Activation
Secretion
Tolerance Induction
Cell Differentiation
Pathogenesis
T Cell Activation
Cell Proliferation
Cytokine Secretion
Inflammatory Response
Cell Maturation
Hypersensitivity
Cytolysis
Macrophage Activation
Sensitization
Peripheral Tolerance Induction
Cell Death
Interferon-gamma Production

Research Areas for CD161/NK1.1

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Signal Transduction

PTMs for CD161/NK1.1

Learn more about PTMs related to CD161/NK1.1.

Nitration
Cleavage
Glycosylation
Methylation

Bioinformatics Tool for CD161/NK1.1

Discover related pathways, diseases and genes to CD161/NK1.1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.