CD161/NK1.1 Products

Description

NK-1.1 surface antigen is encoded by the NKR-P1B/NKR-P1C gene, also known as CD161b/CD161c and Ly-55. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN- gamma production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers. The PK136 antibody has been reported to deplete NK cells, induce redirected lysis, block NK cell function, and induce NK cell proliferation.

Bioinformatics

Product By Gene ID	17059
Alternate Names	CD161 antigen CD161 CD161c CLEC5BC-type lectin domain family 5 member B hNKR-P1A HNKR-P1a killer cell lectin-like receptor subfamily B member 1 killer cell lectin-like receptor subfamily B, member 1 Natural killer cell surface protein P1A NKR-P1 NKR-P1AMGC138614 NKRP1ANKR

Research Areas for CD161/NK1.1

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Signal Transduction