CCR2 Antibody (890231) [Phycoerythrin]

Images

 
HEK293 human embryonic kidney cell line transfected with rat CCR2 and eGFP was stained with either (A) Mouse Anti-Rat CCR2 PE‑conjugated Monoclonal Antibody (Catalog # FAB8368P) or (B) Mouse IgG2B Phycoerythrin ...read more

Product Details

Summary
Reactivity RtSpecies Glossary
Applications Flow
Clone
890231
Clonality
Monoclonal
Host
Mouse
Conjugate
Phycoerythrin

Order Details

CCR2 Antibody (890231) [Phycoerythrin] Summary

Immunogen
NS0 mouse myeloma cell line transfected with rat CCR2
Accession # O55193
Specificity
Stains rat CCR2 transfectants but not irrelevant transfectants in flow cytometry.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
CCR2
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells
Publications
Read Publication using
FAB8368P in the following applications:

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CCR2 Antibody (890231) [Phycoerythrin]

  • C-C chemokine receptor type 2
  • C-C CKR-2
  • CC-CKR-2
  • CC-CKR-2CKR2B
  • CCR2
  • CCR-2
  • CCR2A
  • CCR2B
  • CD192 antigen
  • CD192
  • chemokine (C-C motif) receptor 2
  • CKR2
  • CKR2A
  • CMKBR2
  • CMKBR2MGC111760
  • FLJ78302
  • MCP-1 receptor
  • MCP-1-R
  • MCP-1-RMGC103828
  • MGC168006
  • Monocyte chemoattractant protein 1 receptor
  • monocyte chemotactic protein 1 receptor

Background

CCR2, also known as CD192, is a 38 kDa 7TM chemokine receptor that preferentially binds CCL2, CCL7, and CCL13. CCR2 is expressed by multiple hematopoietic cells, endothelial cells, fibroblasts, neurons, and smooth muscle cells. It functions as an HIV fusion co-factor and facilitates T cell recruitment during inflammation. Two alternate splice forms (CCR2A and CCR2B) differ only by the addition of 14 amino acids to the intracellular carboxyl terminal. Rat CCR2 shares 95% aa sequence identity with mouse CCR2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CCR2 Antibody (FAB8368P)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Flow Cytometry.


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Flow Cytometry
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Product General Protocols

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FAQs for CCR2 Antibody (FAB8368P) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB8368U
Alexa Fluor 405 FAB8368V
Alexa Fluor 405 FAB8368V
Alexa Fluor 488 FAB8368G
Alexa Fluor 532 FAB8368X
Alexa Fluor 594 FAB8368T
Alexa Fluor 647 FAB8368R
Alexa Fluor 647 FAB8368R
Alexa Fluor 700 FAB8368N
Alexa Fluor 700 FAB8368N
Alexa Fluor 750 FAB8368S
Allophycocyanin FAB8368A
Biotin FAB8368B
DyLight 350 FAB8368D
DyLight 405 FAB8368E
DyLight 488 FAB8368K
DyLight 550 FAB8368L
DyLight 594 FAB8368M
DyLight 650 FAB8368W
DyLight 680 FAB8368Y
DyLight 755 FAB8368Z
FITC FAB8368F
Janelia Fluor 549 FAB8368I
Janelia Fluor 646 FAB8368J
PerCP FAB8368C
Phycoerythrin FAB8368P

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Blogs on CCR2.

Rest in Peace: Is the Receptor Interacting Protein (RIP) Kinase-3 (RIPK3) a Protector or Offender?
By Jamshed Arslan, Pharm. D., PhD. Receptor interacting protein kinases (RIPKs) in necroptosisDeath is perhaps inevitable. Cell death can be programed and immunologically silent (apoptosis), unprogrammed and inflamm...  Read full blog post.

CCR2 or CD192
CCR2 is a receptor for several monocyte chemoattractant proteins (MCP1, MCP3, MCP4) that specifically govern monocyte chemotaxis. CCR2 transduces its downstream signals through increasing intracellular calcium ion levels. For example, MCP1 regulate...  Read full blog post.

CCR2: Affecting Autoimmunity via MCP1 interactions
CCR2, also known as CD192 (cluster of differentiation 192), is a chemokine receptor and is expressed by monocytes, activated T cells, B cells and natural killer cells. This protein is encoded by CCR2 gene in humans. CCR2 gene encodes two protein isofo...  Read full blog post.

MCP1: One Chemoattractant that's Hard to Resist
Monocyte Chemoattractant Protein (MCP1) is a potent monocyte attractant, is a member of the CC chemokine subfamily. MCP1 exerts its effects through binding to G-protein-coupled receptors on the surface of leukocytes targeted for activation and migrati...  Read full blog post.

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Bioinformatics

Gene Symbol CCR2
Uniprot