CCL3L1/LD78 beta Antibody

• Reactivity: Hu
• Applications: ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

CCL3L1/LD78 beta Antibody Summary

• Description: Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.
• Immunogen: Peptide with sequence CNQVLSAPLAADT corresponding to internal region according to NP_066286.1.
• Epitope: internal region
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: CCL3L1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:8000
• Application Notes: WB: Preliminary experiments in human bone marrow and in peripheral blood mononucleocyte lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for CCL3L1/LD78 beta Antibody

• C-C motif chemokine 3-like 1
• CCL3L3
• chemokine (C-C motif) ligand 3-like 1
• D17S1718
• G0/G1 switch regulatory protein 19-2
• G0S19-2LD78
• LD78BETA
• LD78-beta(1-70)
• MGC104178
• MGC12815
• MGC182017
• MIP1AP
• PAT 464.2
• SCYA3L
• SCYA3L1464.2
• small inducible cytokine A3-like 1
• Small-inducible cytokine A3-like 1
• Tonsillar lymphocyte LD78 beta protein

Background

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than six copies. The human genome reference assembly contains two full copies of the gene and a partial pseudogene. This record represents the more telomeric full-length gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CCL3L1/LD78 beta Antibody (NBP1-28465)(1)

Publication using NBP1-28465

• McKinney C, Merriman ME, Chapman PT et al. Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis. Ann Rheum Dis 2008-03-01 [PMID: 17604289]

Bioinformatics

• Gene Symbol: CCL3L1
• Entrez:
  • 6349(Human)
  • 55938(Mouse)
  • 55939(Rat)
• Uniprot:
  • NP_066286.1(Human)