The antibody is useful for detection of MCP-1 by Western blot. Furthermore it can be used in immunoassays. The typical starting working dilution is 1:10. It is recommended that users test the reagent and determine their own optimal dilutions. Although not tested this antibody may be useful in immunohistochemistry on frozen and paraffin sections. Use in Immunohistochemistry-Frozen reported in scientific literature (PMID: 26413869)
Read Publications using NBP1-42312 in the following applications:
small inducible cytokine A2 (monocyte chemotactic protein 1, homologous tomouse Sig-je)
small inducible cytokine subfamily A (Cys-Cys), member 2
Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.