CBP/KAT3A Antibody

Images

 
Western Blot: CBP/KAT3A Antibody [NB100-91721] - Analysis of CBP (V2427) pAb at 1:500 dilution Lane1:Hela cell lysate Lane2:Mouse spleen tissue lysate Lane3:Rat liver tissue lysate
Immunohistochemistry-Paraffin: KAT3A/CBP Antibody [NB100-91721] - Paraffin-embedded human breast carcinoma tissue.
Western Blot: KAT3A/CBP Antibody [NB100-91721] - Extracts from HeLa cell treted with Insulin 0.01U/ml 15'.

Product Details

Summary
Product Discontinued
View other related CBP/KAT3A Primary Antibodies

Order Details


    • Catalog Number
      NB100-91721
    • Availability
      Product Discontinued

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CBP/KAT3A Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 2395-2440 of Human CBP.
Clonality
Polyclonal
Host
Rabbit
Gene
CREBBP
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of CREBBP (V2427) pAb in extracts from HeLa cell treted with Insulin 0.01U/ml 15'.
Immunohistochemistry (IHC) analyzes of CREBBP (V2427) pAb in paraffin-embedded human breast carcinoma tissue.
Theoretical MW
265 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CBP/KAT3A Antibody

  • CBP
  • CBPRTS
  • CREB binding protein
  • CREB-binding protein
  • CREBBP
  • EC 2.3.1.48
  • KAT3A
  • RSTS
  • RTS
  • Rubinstein-Taybi syndrome

Background

Cyclic AMP-regulated gene expression frequently involves a DNA element designated the cAMP-regulated enhancer (CRE). Many transcription factors bind to this element, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A. It has been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a nuclear protein designated CBP (for CREB-binding protein). These findings suggest that CBP has many of the properties expected of a CREB co-activator. Another high molecular weight transcriptional adapter protein, designated p300, is characterized by three cysteine- and histidine-rich regions, of which the most carboxy-terminal region specifically binds the adenovirus E1A protein. p300 molecules lacking an intact E1A binding site bypass E1A repression, even in the presence of high concentrations of E1A. Sequence analysis of CBP and p300 has revealed substantial homology, arguing that these proteins are members of a conserved family of co-activators.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CREBBP
Entrez
Uniprot