CBL Antibody [DyLight 350]

• Reactivity: Hu, Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: DyLight 350

CBL Antibody [DyLight 350] Summary

• Immunogen: E. coli-derived recombinant human CBL
  Asp775-Thr906
  Accession # P22681
• Specificity: Detects human and mouse CBL in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: CBL
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for CBL Antibody [DyLight 350]

• Cas-Br-M (murine) ecotropic retroviral transforming sequence
• Casitas B-lineage lymphoma proto-oncogene
• CBL
• CBL2
• CBL2E3 ubiquitin-protein ligase CBL
• EC 6.3.2
• EC 6.3.2.-
• oncogene CBL2
• Proto-oncogene c-Cbl
• RING finger protein 55
• RNF55
• RNF55C-CBL
• Signal transduction protein CBL

Background

c-Cbl, product of c-cbl proto-oncogene, is a 120 kDa cytoplasmic protein involved in tyrosine kinase-dependent signaling pathways (1-3). c-Cbl is one of the earliest targets of tyrosine phosphorylation in response to a number of cellular stimuli. For instance, stimulation of growth factor receptors by EGF, PDGF, NGF and FGF, results in c-Cbl tyrosine phosphorylation, in lymphoid and other cell lines (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CBL