Cathepsin B Antibody (CB131)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P, WB (-)
Clone
CB131
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Cathepsin B Antibody (CB131) Summary

Immunogen
Recombinant human cathepsin B.
Specificity
This is specific for Cathepsin B, a lysosomal protease expressed in a wide range of tissues, including liver, skeletal muscle, and heart.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
CTSB
Purity
Tissue culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:40-1:80
Application Notes
This product does not work in immunohistology of frozen sections or western blotting.
Positive Control
Cathepsin B Lysate (NBL1-09587)

Reactivity Notes

Reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Tissue culture supernatant
Preservative
0.09% Sodium Azide
Purity
Tissue culture supernatant

Alternate Names for Cathepsin B Antibody (CB131)

  • APP secretase
  • APPS
  • Cathepsin B
  • Cathepsin B1
  • CPSBamyloid precursor protein secretase
  • CTSB
  • cysteine protease
  • EC 3.4.22
  • EC 3.4.22.1

Background

Cathepsin B is a cysteine endopeptidase which is synthesised as a 40kD inactive glycoprotein which is processed into the mature form. Cathepsin B is widely expressed by various tissues.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Cathepsin B Antibody (NB600-1111)

Discover related pathways, diseases and genes to Cathepsin B Antibody (NB600-1111). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Blogs on Cathepsin B.

Cathepsin B - a lysosomal protease with potential of an important drug target in neurological diseases and cancer
Cathepsins are a family of lysosomal proteases (serine, aspartic and cysteine proteases) that acts in conjunction with lipases and nucleases to degrade biological macromolecules in the lysosomes (1). While most cathepsins are ubiquitously expressed...  Read full blog post.

Caspase 11: A novel non-canonical inflammasomes
Cell death via apoptosis is a key cellular function triggered by the cell death receptor family and their ligands. This regulated process then transmits downstream signals through adaptor molecules ending with the caspase cysteine proteases. Caspas...  Read full blog post.

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Bioinformatics

Gene Symbol CTSB
Entrez
Uniprot