Caspase-8 Antibody (90A992) [PerCP]

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Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications WB, Flow, IHC-P
Clone
90A992
Clonality
Monoclonal
Host
Mouse
Conjugate
PerCP

Caspase-8 Antibody (90A992) [PerCP] Summary

Immunogen
The immunogen for this product falls between amino acids 360-385 of the human Caspase 8 protein.
Specificity
This can be used for detection of the pro-form of Caspase-8.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CASP8
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Flow Cytometry 1ul/1 million cells
  • Immunohistochemistry-Paraffin

Reactivity Notes

Chimpanzee and Rhesus Monkey.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Caspase-8 Antibody (90A992) [PerCP]

  • AIS
  • androgen receptor
  • CASP8
  • Caspase8
  • Caspase-8
  • DHTRTFM
  • Dihydrotestosterone receptorHYSP1
  • HUMARA
  • Mch5
  • NR3C4KD
  • Nuclear receptor subfamily 3 group C member 4
  • SMAX1SBMA
  • spinal and bulbar muscular atrophy

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Caspase-8 Antibody (NB100-56527PCP). (Showing 1 - 1 of 1 FAQ).

  1. May we ask the MW difference between the active form and the proform of Caspase 8 while performing WB?
    • In treated cells induced to undergo apoptosis, caspase-8 migrates as a 55/53 kDa (pro-form), 41/42 kDa (a cleaved/active or intermediate form), and 18 kDa (active form). The proform (55/53 kDa) is still seen in treated cells because not all cells undergo apoptosis at once.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NB100-56527APC
Biotin Labeled NB100-55786
DyLight 350 Labeled NB100-56527UV
DyLight 405 Labeled NB100-56527V
DyLight 488 Labeled NB100-56527G
DyLight 550 Labeled NB100-56527R
DyLight 650 Labeled NB100-56527C
DyLight 680 Labeled NB100-56527FR
DyLight 755 Labeled NB100-56527IR
HRP Labeled NB100-56527H
PE Labeled NB100-56527PE

Additional Caspase-8 Products

Bioinformatics Tool for Caspase-8 Antibody (NB100-56527PCP)

Discover related pathways, diseases and genes to Caspase-8 Antibody (NB100-56527PCP). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for Caspase-8 Antibody (NB100-56527PCP)

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Pathways for Caspase-8 Antibody (NB100-56527PCP)

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PTMs for Caspase-8 Antibody (NB100-56527PCP)

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Research Areas for Caspase-8 Antibody (NB100-56527PCP)

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Blogs on Caspase-8.

Caspase 3, the executioner of apoptosis
Caspase-3 enzyme is a member of the family of endoproteases which regulate inflammation and apoptosis signaling networks. Caspase-3 is known as an executioner caspase in apoptosis because of its role in coordinating the destruction of cellular stru...  Read full blog post.

VPS41 - An important regulator of lysosomal trafficking
Membrane fusion is an essential step during the trafficking of endosomes and vesicles throughout the cell. Membrane fusion events are facilitated by multisubunit tethering complexes (MTC) including CORVET and HOPS. These complexes interact with Rab...  Read full blog post.

Caspase-8 - a pro-apoptotic protein with dynamic roles in normal physiology and pathology
Caspases are a family of cysteine-aspartic acid proteases that are responsible for the initiation and execution of apoptosis. Caspase-8 is a 55 kDa protein expressed as an inactive procaspase that resides in the cytosol. Activation of Caspase-8 req...  Read full blog post.

Caspase 8 - a key mediator of apoptosis
Programmed cell death via apoptosis is a key controlled physiological process instigated by the cell death receptor family, their ligands, and the caspase cysteine protease family. All caspases exist in a precursor form that contains a prodomain, a...  Read full blog post.

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Bioinformatics

Gene Symbol CASP8
Entrez