Caspase-7 Antibody [DyLight 650]

• Reactivity: Hu, Mu
• Applications: WB, KO
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 650

Caspase-7 Antibody [DyLight 650] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: KLH-coupled mouse Caspase-7 synthetic peptide
  RHFESQSDDPRFNEKC
• Specificity: Detects human and mouse Caspase-7 precursor and the small Caspase-7 subunit that is generated during proteolytic activation.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CASP7
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Knockout Validated
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product AF823. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Caspase-7 Antibody [DyLight 650]

• apoptosis-related cysteine protease
• Apoptotic protease Mch-3
• CASP7
• CASP-7
• caspase 7, apoptosis-related cysteine peptidase
• Caspase7
• Caspase-7
• EC 3.4.22
• EC 3.4.22.60
• ICE-like apoptotic protease 3
• Lice2 alpha/beta/gamma
• Mch3

Background

Caspase 7 (CASP7) is a member of the cysteine-aspartic acid protease (caspase) family that is involved in the execution-phase of cell apoptosis. The sequential activation of caspases plays a central role in the execution-phase of cell apoptosis, and Caspase 7 is an executioner protein of apoptosis. It is activated upon cell death stimuli and induces apoptosis.

Caspase 7 is expressed as an inactive proenzyme which then undergos proteolytic processing by upstream caspases, to form an active (cleaved) caspase 7 form.

Caspase 7 antibodies are important tools for apoptosis studies and research on the caspase family mediated apoptosis signaling pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CASP7