Caspase-2 Antibody (4-1-5)

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Western Blot: Caspase-2 Antibody [NBP1-19194] - MW marker (1), Jurkat (2) and Jurkat + staurosporine (3) probed with Caspase 2 Monoclonal Antibody (4-1-5)

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
4-1-5
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Caspase-2 Antibody (4-1-5) Summary

Immunogen
Recombinant full length human Caspase-2
Specificity
Caspase-2 (4-1-5)
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CASP2
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
No buffer
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for Caspase-2 Antibody (4-1-5)

  • caspase-2
  • CASP2
  • CASP-2
  • caspase 2, apoptosis-related cysteine peptidase
  • Caspase2
  • Caspase-2
  • ICH1
  • ICH-1
  • NEDD2
  • NEDD-2
  • PPP1R57

Background

Caspase-2 (Nedd2/ICH-1) is part of a family of aspartate-specific cysteine proteases that participate in programmed cell death, or apoptosis. Caspase-2 is localized to the nucleus, and has been shown to play roles in both positive and negative regulation of apoptosis (1). Upon apoptotic stimulation, pro-caspase-9 is cleaved in a series of steps to produce an 18-kDa large subunit and a 12-kDa small fragment (2). Caspase-2 can be a nuclear initiator caspase, as it has been shown to precede the processing and activation of caspase-8, -9, and -3 (3). Caspase-2 might also act as an effector caspase; in apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of caspase-9 and caspase-3 activation (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Caspase-2 Antibody (NBP1-19194). (Showing 1 - 1 of 1 FAQ).

  1. Could you let us know the buffer formulation of #NBP1-19194?
    • NBP1-19194 is supplied in PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Caspase-2 Antibody (NBP1-19194)

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Diseases for Caspase-2 Antibody (NBP1-19194)

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Research Areas for Caspase-2 Antibody (NBP1-19194)

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Blogs on Caspase-2.

active/cleaved Caspase 2 - Inducing apoptosis in response to cellular stress
Caspase-2 is a highly conserved member of the caspase family involved in the initiation and execution of apoptosis. While its function is still poorly understood, caspase-2 is thought to be important for apoptosis in response to DNA damage, bacteri...  Read full blog post.

IRE1 - an important sensor in the unfolded protein response pathway
During cellular stress the protein folding capacity of the ER is diminished. In order to maintain homeostasis and ensure proper protein folding cells activate the unfolded protein response (UPR), a signaling network consisting of sensors and effect...  Read full blog post.

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Bioinformatics

Gene Symbol CASP2
Entrez