Cannabinoid R2/CB2/CNR2 Antibody (352110R) [Allophycocyanin/Cy7]

• Reactivity: Hu
• Applications: Flow
• Clone: 352110R
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin/Cy7

Cannabinoid R2/CB2/CNR2 Antibody (352110R) [Allophycocyanin/Cy7] Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Human embryonic kidney cell line HEK293-derived transfected with human Cannabinoid R2/CB2/CNR2
  Met1-Cys360
  Accession # NP_001832
• Specificity: Detects human Cannabinoid R2/CB2/CNR2 in HEK293 human cell line transfected with human Cannabinoid R2/CB2/CNR2 and not Cannabinoid R1/CB1/CNR1 transfectants in flow cytometry.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A or G purified from cell culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined. For optimal results using our Tandem dyes, please avoid prolonged exposure to light or extreme temperature fluctuations. These can lead to irreversible degradation or decoupling. When staining intracellular targets, specific attention to the fixation and permeabilization steps in your flow protocol may be required. Please contact our technical support team at technical@novusbio.com if you have any questions.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from cell culture supernatant

Alternate Names for Cannabinoid R2/CB2/CNR2 Antibody (352110R) [Allophycocyanin/Cy7]

• Cannabinoid R2
• cannabinoid receptor 2 (macrophage)
• CannabinoidR2
• CB-2
• CB2cannabinoid receptor 2
• CB2R
• CNR2
• CX5
• CX5testis-dominant CNR2 isoform CB2
• hCB2

Background

Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P / Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.