Calcitonin Antibody (4901)

Images

 
Immunocytochemistry/ Immunofluorescence: Calcitonin Antibody (4901) [NBP1-30051] - Immunostaining of CGRP (red) in cryopreserved DRG neurons grown on coverslips. 40xmag. Green staining is PGP9.5. Yellow staining is the ...read more

Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications ICC/IF, ICC, WB (-)
Clone
4901
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Calcitonin Antibody (4901) Summary

Immunogen
Purified rat alpha-CGRP
Specificity
Specific for Calcitonin Gene Related Peptide. Also recognizes rat beta-CGRP and human alpha-CGRP (10-fold less sensitivity compared to rat alpha-CGRP). Suggested positive controls are dorsal root ganglia, pancreas and gut.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
CALCA
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:50-1:100
  • Immunocytochemistry 1:10 - 1:500
Application Notes
This antibody is an excellent tool for immunohistochemistry and for multiple labeling immunofluorescence of peripheral tissue like stomach, intestine, pancreas, sensory ganglia, and all the regions of the body that are innervated by primary afferent neurons as well as central nervous tissue.
Publications
Read Publication using
NBP1-30051 in the following applications:

Reactivity Notes

Tested in Human and Rat. Expected reactivity to most mammals.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Protein G purified

Notes

This antibody is an excellent tool for immunohistochemistry and for multiple labeling immunofluorescence of peripheral tissue like stomach, intestine, pancreas, sensory ganglia, and all the regions of the body that are innervated by primary afferent neurons as well as central nervous tissue.

Alternate Names for Calcitonin Antibody (4901)

  • ATP2B2plasma membrane calcium ATPase
  • ATPase, Ca++ transporting, plasma membrane 4
  • DKFZp686G08106
  • DKFZp686M088
  • EC 3.6.3
  • EC 3.6.3.8
  • Matrix-remodeling-associated protein 1
  • matrix-remodelling associated 1
  • MXRA1
  • Plasma membrane calcium ATPase isoform 4
  • Plasma membrane calcium pump isoform 4
  • plasma membrane calcium pump
  • plasma membrane calcium-transporting ATPase 4
  • PMCA4b
  • PMCA4PMCA4x
  • sarcolemmal calcium pump

Background

Calcitonin (Katacalcin) is a 32 amino acids poly-peptide hormone that is commonly expressed in the parafollicular or C cells in the thyroid gland. It is also synthesized in a wide variety of other tissues, including the lung and intestinal tract (1). Calcitonin is a potent plasma calcium-lowering peptide; it decreases the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Calcitonin staining is used in the identification of C cell proliferative abnormalities, such as C cell hyperplasia and invasive tumors (2). Staining for calcitonin may be used for the identification of a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors (e.g. medullary thyroid carcinomas). Calcitonin activitiy might be exhibited in amyloid deposits within the tumor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Calcitonin Antibody (NBP1-30051)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ICC/IF.


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ICC/IF
(1)
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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol CALCA
Uniprot