Cadherin-12 Antibody (343621) [mFluor Violet 500 SE]

• Reactivity: Hu
• Applications: WB, Flow, CyTOF-ready, ICC/IF
• Clone: 343621
• Clonality: Monoclonal
• Host: Rat
• Conjugate: mFluor Violet 500 SE

Cadherin-12 Antibody (343621) [mFluor Violet 500 SE] Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Cadherin-12
  Met1-Pro609
  Accession # P55289
• Specificity: Detects human Cadherin‑12 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) Cadherin-8, -11, -13, -17, rhE-Cadherin, rhP-Cadherin, rhR-Cadherin, or rhVR-Cadherin is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Rat
• Gene: CDH12

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Cadherin-12 Antibody (343621) [mFluor Violet 500 SE]

• Br-Cadherin
• cadherin 12, type 2 (N-cadherin 2)
• Cadherin12
• Cadherin-12
• CDH12
• CDHB
• FLJ34857
• N-Cadherin 2
• Neural type cadherin 2
• neural type, 2
• neuronal cadherin 2

Background

CDH12 encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CDH12