Bradykinin RB2/BDKRB2 Antibody (471902) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 471902
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

Bradykinin RB2/BDKRB2 Antibody (471902) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human RB2/BDKRB2 in direct ELISAs and Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Bradykinin RB2/BDKRB2 Antibody (471902) [Alexa Fluor™ Plus 647]

• B2 bradykinin receptor
• B2R
• BDKRB2
• BK-2 receptor
• BK2
• BK-2
• BKR2
• Bradykinin RB2
• bradykinin receptor B2
• BradykininRB2
• BRB2
• DKFZp686O088

Background

Bradykinin RB2 (BDKRB2) is a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. BDKRB2 expression is widespread in normal smooth muscle tissue and neurons. BDKRB2 associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. BDKRB2 forms a complex with PECAM1 and GNAQ and interacts with PECAM1. Aging cardiac endothelial cells gradually lose their capacity to express BDKRB2. This loss appears to be parallel with a loss of the angiogenic potential of the aging cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.