BPI Antibody (3F9)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51113
    • Availability
      Product Discontinued

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BPI Antibody (3F9) Summary

Immunogen
The immunogen for this antibody is proprietary information.
Specificity
3F9 reacts specifically with full length human natural and recombinant Bactericidal Permeability Increasing protein (BPI)
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
BPI
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Immunoassay

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
0.2 um filtered solution in PBS and 0.1% BSA
Preservative
0.02% Sodium Azide
Purity
Protein A or G purified

Alternate Names for BPI Antibody (3F9)

  • bactericidal permeability-increasing protein
  • bactericidal/permeability-increasing protein
  • BPI
  • BPIFD1
  • CAP 57
  • rBPI

Background

The monoclonal antibody 3F9 reacts specifically with full length human natural and recombinant Bactericidal Permeability Increasing protein (BPI). The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. Binding of BPI to the lipid A moiety of LPS exerts multiple anti-infective activities against gram-negative bacteria: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS-triggered airways disease. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21 kDa bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin. The monoclonal antibody 3F9 recognizes only free BPI and does not interact with BPI that has formed a complex with LPS.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol BPI
Entrez