Bone marrow stromal cell antigen 1/CD157 Antibody [Alexa Fluor™ Plus 555]

• Reactivity: Mu
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor Plus 555

Bone marrow stromal cell antigen 1/CD157 Antibody [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects mouse CD157 in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant human CD157 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Bone marrow stromal cell antigen 1/CD157 Antibody [Alexa Fluor™ Plus 555]

• ADP-ribosyl cyclase 2
• Bone marrow stromal antigen 1
• bone marrow stromal cell antigen 1
• BP-3
• BST1
• BST-1
• cADPr hydrolase 2
• CD157 antigen
• CD157
• Cyclic ADP-ribose hydrolase 2
• EC 3.2.2.5
• NAD(+) nucleosidase

Background

CD157, also known as bone marrow stromal cell antigen 1 (BST-1), is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family (1). CD157 was discovered in a bone marrow stromal cell line where it facilitates pre-B-cell growth (2, 3). Along with CD38, CD157 is a bifunctional ectoenzyme that exhibits both ADP-ribosyl cyclase and cyclic ADP ribose hydrolase activities (2). It may play a role in rheumatoid arthritis (RA) due to its enhanced expression in RA‑derived bone marrow stromal cell lines (3). CD157 has been predicted to function as a cell surface receptor and an immunoregulatory molecule (4).

1. Hussain, A. M. M. et al. (1998) Protein Express. Purif. 12:133.
2. Sato, A. et al. (1999) Biochem. J. 337:491.
3. Kaisho, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91:5325.
4. Ortolan, E. et al. (2002) Cell Biochem. and Function. 20:309.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.