BMX Antibody [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 750

BMX Antibody [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human BMX
  Met1-Gln215
  Accession # P51813
• Specificity: Detects human BMX in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BMX Antibody [Alexa Fluor® 750]

• BMX non-receptor tyrosine kinase
• BMX
• Bone marrow tyrosine kinase gene in chromosome X protein
• EC 2.7.10
• EC 2.7.10.2
• Epithelial and endothelial tyrosine kinase
• ETK
• Etk/Bmx cytosolic tyrosine kinase
• ETKcytoplasmic tyrosine-protein kinase BMX
• NTK38 tyrosine kinase
• NTK38
• PSCTK2
• PSCTK3

Background

BMX (Bone marrow tyrosine kinase gene in chromosome X protein; also ETK and NTK38) is a 76‑85 kDa member of the TEC subfamily, Tyr protein kinase family of enzymes. It is a cytoplasmic endothelial and epithelial cell kinase that induces STAT phosphorylation in a Jak-independent manner, and regulates cytokine production via mRNA stabilization. Human BMX is 675 amino acids (aa) in length. It contains one PH domain whose ligation induces activation (aa 6‑109), a zinc-finger region (aa 113‑149), two autophosphorylation sites at Tyr216 and Tyr224, an SH3 and SH2 domain (aa 213‑392) and a kinase catalytic site (aa 417‑675). BMX undergoes proteolysis by caspase 3 to generate a 35 kDa N-terminal (aa 1‑242) fragment, and a 50 kDa C-terminal (aa 243‑675) fragment with enhanced kinase activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.