beta ureidopropionase Antibody - BSA Free

Analysis in human liver and colon tissues using Anti-UPB1 antibody. Corresponding UPB1 RNA-seq data are presented for the same tissues.

Immunohistochemistry-Paraffin: beta ureidopropionase Antibody [NBP1-89918] - Staining of human colon shows low expression as expected.

Immunohistochemistry-Paraffin: beta ureidopropionase Antibody [NBP1-89918] - Staining of human liver shows high expression.

Analysis in control (vector only transfected HEK293T lysate) and UPB1 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells).

• Reactivity: Hu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

beta ureidopropionase Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit beta ureidopropionase Antibody - BSA Free (NBP1-89918) is a polyclonal antibody validated for use in IHC and WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: GALSESLWPIEARNAAIANHCFTCAINRVGTEHFPNEFTSGDGKKAHQDFGYFYGSSYVAAPDSSRTPGLSRSRDGLLVAKLDLNLCQQVNDVWNFKMTGRYEMYARELAEAVKSNYS
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: UPB1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
  • Western Blot 0.04-0.4 ug/ml
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  beta ureidopropionase Protein (NBP1-89918PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (86%), Rat (85%)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for beta ureidopropionase Antibody - BSA Free

• Beta-alanine synthase
• beta-ureidopropionase
• BUP-1
• BUP1EC 3.5.1.6
• N-carbamoyl-beta-alanine amidohydrolase
• ureidopropionase, beta

Background

beta ureidopropionase encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: UPB1