beta Amyloid Antibody (MOAB-2) [DyLight 405]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clone
MOAB-2
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 405

beta Amyloid Antibody (MOAB-2) [DyLight 405] Summary

Immunogen
Recombinant human beta Amyloid 42
Epitope
Residues 1-4 of beta Amyloid
Specificity
Unaggregated, oligomeric and fibrillar forms of beta Amyloid 42 and unaggregated beta Amyloid 40. Does not detect APP.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
APP
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This beta Amyloid Antibody (MOAB-2) is useful for Immunocytochemistry/Immunofluorescence, ELISA, Immunoprecipitation, Western Blot, and Immunohistochemistry on paraffin-embedded sections. In Western blot, a band can be seen at ~4 kDa, representing the beta Amyloid monomer. Larger bands may also be seen representing the unaggregated, oligomeric, and fibrillar forms of beta Amyloid. For higher beta Amyloid yield in WB, please follow the extraction protocol described in Youmans et al, J Neurosci Methods. 2011 March 15; 196(1): 51-59 (PMID: 21219931).

Reactivity Notes

Human, mouse and rat.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for beta Amyloid Antibody (MOAB-2) [DyLight 405]

  • Abeta
  • Amyloid beta
  • beta-Amyloid Peptide

Background

Beta Amyloid, also known as Abeta, is a peptide that varies in length from 39 to 43 amino acids and is processed from the Amyloid precursor protein (APP). Beta Amyloid is known as the main component of amyloid plaques, which are deposits found in the brains of patients with Alzheimer's disease. The form(s) of beta Amyloid associated with the pathology characteristic of Alzheimer's disease still remains unclear. Currently, controversy exists as to the existence of intraneuronal beta Amyloid. Research indicates that intraneuronal beta Amyloid accumulation may be an important proximal neurotoxic event in the pathogenesis of Alzheimer's disease. Many commercially available beta Amyloid antibodies cross react with APP or APP C-terminal fragments. This MOAB-2 antibody is specific for beta Amyloid but not APP. MOAB-2 is a pan-specific beta Amyloid antibody that detects unaggregated, oligomeric and fibrillar forms of beta Amyloid. This is important because beta Amyloid is known to aggregate and form a variety of potentially toxic conformations. MOAB-2 displays strong extracellular beta Amyloid immunoreactivity, and so detects classic plaque pathology. MOAB-2 is selective for Abeta 42 over Abeta 40. This is also an advantage as the 42 amino acid form of beta Amyloid is likely the toxic form. MOAB-2 demonstrates strong intraneuronal immunoreactivity in both human and beta Amyloid-Tg mouse tissue and has the potential to aid future research into the functional importance of intraneuronal beta Amyloid.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NBP2-13075B
DyLight 488 Labeled NBP2-13075G
DyLight 550 Labeled NBP2-13075R
DyLight 650 Labeled NBP2-13075C
FITC Labeled NBP2-13075F
HRP Labeled NBP2-13075H

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Bioinformatics Tool for beta Amyloid Antibody (NBP2-13075V)

Discover related pathways, diseases and genes to beta Amyloid Antibody (NBP2-13075V). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Blogs on beta Amyloid.

Beta Amyloid (MOAB2) and the link between traumatic brain injury and Alzheimer’s disease
An epidemiological association between traumatic brain injury (TBI) and Alzheimer's disease (AD) has long been established.  Interestingly, an increase in beta amyloid  (one hallmark of AD) directly following TBI has been observed.  In fact, it h...  Read full blog post.

Analysis of Total & pSer724 IRE1 alpha, the Sensor of ER Stress
Inositol-requiring protein 1/IRE1 alpha (also called Endoplasmic Reticulum to Nucleus Signaling 1/ERN1; predicted mol wt 110 kDa) is a serine-threonine protein kinase/endoribonuclease which plays a highly critical role in unfolded protein response/U...  Read full blog post.

Beta Amyloid Neurotoxicity and Alzheimer's Disease
A major histopathological hallmark of Alzheimer's disease (AD) is the presence of amyloid deposits in the parenchyma of the amygdala, hippocampus, and neocortex. The principal component of amyloid is beta amyloid (AB). The pathologic accumulation of A...  Read full blog post.

Using Amyloid beta peptides in Alzheimer's Disease Immunization
Amyloid beta (AB) peptide has a central role in the neurodegeneration of Alzheimer's disease (AD). Immunization of AD transgenic mice with AB-42 peptide reduces both the spatial memory impairments and AD-like neuropathologic changes.Therapeutic im...  Read full blog post.

Synaptophysin and Dementing Disorders
 Synaptophysin (a presynaptic vesicle protein) is an integral membrane glycoprotein originally isolated from presynaptic vesicles of bovine neurons. Synaptophysin is found in all nerve terminals and synaptophysin measurements have been used to quantif...  Read full blog post.

Amyloid beta and Methionine Sulfoxide Related to Abeta 42 Antibody and Abeta 40 Antibody
By Eric NeeleyAlzheimer's disease is a devastating neurodegenerative illness characterized by the formation of plaques, tangles, and eventually synaptic loss. Amyloid beta (A beta ) is the processed form of the Amyloid precursor protein (APP), and whose...  Read full blog post.

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Bioinformatics

Gene Symbol APP
Entrez