beta 2-Microglobulin Antibody (SPM374) [DyLight 650]

Product Discontinued

beta 2-Microglobulin Antibody (SPM374) [DyLight 650] Summary

• Immunogen: Human PBL's from a T-cell acute lymphoblastic leukemia (T-ALL) patient
• Localization: Cell Surface and Extracellular (Secreted)
• Marker: Renal Failure & Tumor Marker
• Specificity: Recognizes a protein of 12kDa, identified as b2-microglobulin. Beta-2-microglobulin non-covalently associates with the 44kDa a chain to form the HLA Class I antigen complex. Human beta-2-microglobulin associated with HLA Class I antigens is expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes. This MAb is specific to human b2-microglobulin and does not react with non-human primate cells. This antibody reacts with all cell types excluding erythrocytes. The detection of beta2 microglobulin in body fluids has been used as a tumor marker and for monitoring patients with HIV infection.
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: B2M
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunofluorescence
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Does not react with Non-Human primates.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for beta 2-Microglobulin Antibody (SPM374) [DyLight 650]

• B2M
• beta 2Microglobulin
• beta 2-Microglobulin
• beta chain of MHC class I molecules
• beta-2-microglobin
• beta-2-microglobulin

Background

Beta-2-microglobulin is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells (Gussow et al., 1987 [PubMed 3312414]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: B2M