BCOR Antibody (CL13841) - BSA Free

Analysis in human lymph node and pancreas tissues using NBP3-24581 antibody. Corresponding BCOR RNA-seq data are presented for the same tissues.

Staining of human placenta shows moderate to strong nuclear positivity in trophoblastic cells.

Staining of human ovarian cancer (papillary carcinoma) shows strong nuclear positivity in tumor cells.

Staining of human pancreas shows no positivity in exocrine glandular cells as expected.

Staining of human cervical cancer shows strong nuclear positivity in tumor cells.

Staining in HEK293 cell line with Anti-BCOR monoclonal antibody, showing specific staining of nucleoplasm in green. Microtubule- and nuclear probes are visualized in red and blue respectively (where available).

Staining of human lymph node shows moderate nuclear positivity in non-germinal center cells.

Staining of human breast cancer (ductal carcinoma) shows strong nuclear positivity in tumor cells.

• Reactivity: Hu, Mu, Rt
• Applications: ICC/IF, IHC
• Clone: CL13841
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free

BCOR Antibody (CL13841) - BSA Free Summary

• Description: Novus Biologicals Mouse BCOR Antibody (CL13841) - BSA Free (NBP3-24581) is a monoclonal antibody validated for use in IHC and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed using a synthetic peptide derived from Q6W2J9, with the exact immunogen sequence remaining proprietary.
• Predicted Species: Mouse (100%), Rat (100%). Backed by our 100% Guarantee.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: BCOR
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 2-10 ug/ml
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
• Application Notes: For IHC-Paraffin, we recommend using Heat-Induced Epitope Retrieval (HIER) with a pH level of 6. This optimized retrieval method ensures the best results for your experiments, For ICC/IF, we recommend using a combination of PFA and Triton X-100. This will give you the optimal results for your experiments.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Protein A purified

Alternate Names for BCOR Antibody (CL13841) - BSA Free

• ANOP2
• BCL6 corepressor
• BCL-6 corepressor
• BCL6 co-repressor
• BCL-6 interacting corepressor
• BCoR
• FLJ20285
• FLJ38041
• KIAA1575MGC71031
• MAA2
• MCOPS2
• MGC131961

Background

BCOR is encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BCOR