Bcl3 Antibody (HAM150-3.5) [DyLight 550]

Product Discontinued

Bcl3 Antibody (HAM150-3.5) [DyLight 550] Summary

• Immunogen: Recombinant mouse Bcl3 [UniProt# Q9Z2F6]
• Localization: Nuclear
• Isotype: IgG1 Lambda
• Clonality: Monoclonal
• Host: Armenian Hamster
• Gene: BCL3
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: NB100-352 works in Western blot analysis, where 3 bands are seen, with a predominant band at 60 kDa, representing the Bcl-3 protein. Also shown to work in immunocytochemistry, demonstrtating both nuclear and cytoplasmic staining. There has been no success with intracellular staining.

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Bcl3 Antibody (HAM150-3.5) [DyLight 550]

• B-cell CLL/lymphoma 3
• B-cell leukemia/lymphoma 3
• B-cell lymphoma 3 protein
• B-cell lymphoma 3-encoded protein
• BCL-3
• BCL4
• chronic lymphatic leukemia protein
• D19S37
• Proto-oncogene BCL3

Background

The transcriptional coactivator, Bcl-3, is a member of the inhibitor of nuclear factor kappaB (NF-kappaB) family. It is also a known regulator of NF-kappaB. It plays a critical role in the development of normal immune responses. Bcl-3 influences the survival of T cells when they are activated as a result of an immune response. As well, it contributes to chronic inflammatory disease states such as osteoarthritis and rheumatoid arthritis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BCL3