Bcl3 Products

Description

The transcriptional coactivator, B-cell lymphoma 3-encoded protein (Bcl3) is a member of the inhibitor of nuclear factor kappaB (NF-kappaB) family. Also a known regulator of NF-kappaB, Bcl-3 plays a critical role in the development of normal immune responses. Specifically, Bcl 3 regulates transcriptional activation of NF-kappa-B target genes, by inhibiting the nuclear translocation of the NF-kappa-B p50 subunit in the cytoplasm and acting as transcriptional activator that promotes transcription of NF-kappa-B target genes in the nucleus.

Bcl-3 also contributes to the regulation of cell proliferation, and influences the survival of T cells when they are activated as a result of an immune response. It also contributes to chronic inflammatory disease states such as osteoarthritis and rheumatoid arthritis, and defects in Bcl3 may lead to B-cell chronic lymphocytic leukemia. Therefore, Bcl3 antibodies can be useful tools for studying autoimmune disease and cancer development.

Bioinformatics

Entrez	602 Human
Uniprot	NP_005169 Human P20749 Human
Product By Gene ID	602
Alternate Names	B-cell CLL/lymphoma 3 B-cell leukemia/lymphoma 3 B-cell lymphoma 3 protein B-cell lymphoma 3-encoded protein BCL-3 BCL4 chronic lymphatic leukemia protein D19S37 Proto-oncogene BCL3

Research Areas for Bcl3

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cell Cycle and Replication
Chromatin Research
Immunology
Signal Transduction
Transcription Factors and Regulators