Bcl3 Products

Antibodies
Bcl3 Antibody
Bcl3 Antibody
NBP2-29946
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Bcl3 Antibody
Bcl3 Antibody
NB100-56375
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Bcl3 Antibody
Bcl3 Antibody
NBP1-45376
Species: Hu, Mu, Rt
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
Lysates
Bcl3 Overexpression Lysate (N ...
Bcl3 Overexpression Lysate (Native)
NBP2-07783
Applications: WB
Bcl3 Overexpression Lysate (D ...
Bcl3 Overexpression Lysate (Denatu...
H00000602-T01
Applications: WB
Proteins
Bcl3 Recombinant Protein
Bcl3 Recombinant Protein
H00000602-P01
Species: Hu
Applications: WB, ELISA, PA

Description

The transcriptional coactivator, B-cell lymphoma 3-encoded protein (Bcl3) is a member of the inhibitor of nuclear factor kappaB (NF-kappaB) family. Also a known regulator of NF-kappaB, Bcl-3 plays a critical role in the development of normal immune responses. Specifically, Bcl 3 regulates transcriptional activation of NF-kappa-B target genes, by inhibiting the nuclear translocation of the NF-kappa-B p50 subunit in the cytoplasm and acting as transcriptional activator that promotes transcription of NF-kappa-B target genes in the nucleus.

Bcl-3 also contributes to the regulation of cell proliferation, and influences the survival of T cells when they are activated as a result of an immune response. It also contributes to chronic inflammatory disease states such as osteoarthritis and rheumatoid arthritis, and defects in Bcl3 may lead to B-cell chronic lymphocytic leukemia. Therefore, Bcl3 antibodies can be useful tools for studying autoimmune disease and cancer development.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 602
Alternate Names
  • chronic lymphatic leukemia protein
  • D19S37
  • B-cell lymphoma 3-encoded protein
  • BCL4
  • B-cell lymphoma 3 protein
  • BCL-3
  • B-cell leukemia/lymphoma 3
  • Proto-oncogene BCL3
  • B-cell CLL/lymphoma 3

Research Areas for Bcl3

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cell Cycle and Replication
Chromatin Research
Immunology
Signal Transduction
Transcription Factors and Regulators

PTMs for Bcl3

Learn more about PTMs related to Bcl3.

Phosphorylation
Methylation

Bioinformatics Tool for Bcl3

Discover related pathways, diseases and genes to Bcl3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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